The main objective of this research, coordinated by Prof. Patrizia Di Trapano, is to apply Neuroscience knowledge to Architecture and Lighting design. The specific objectives include: establishing the foundations of multisensory architecture and analyzing how users' perception of environmental characteristics influences health and well-being; emphasizing the importance of architectural form and composition; conceptualizing lighting based on the principles of integrative lighting, which addresses visual comfort needs, biological aspects (light and the circadian cycle), and emotional factors. Additionally, the research aims to present solid-state lighting technology—LED—highlighting its benefits, characteristics, and applications, as well as providing a future outlook based on its continuous development. It also seeks to discuss current environmental certifications, such as WELL Building Standard, LEED, AQUA, HBC (Health Building Certificate), and GBC LIFE, from the perspective of health and well-being. The study will explore luminous comfort conditions through dynamic computer simulations, using annual climate files and considering hourly and seasonal variations in natural lighting distribution. Discussions will be presented based on natural light performance metrics, such as Daylight Autonomy (DA) and Useful Daylight Illuminance (UDI). For simulation tools, the research will utilize Rhinoceros software with the ClimateStudio plugin, Rhinoceros/Grasshopper/Ladybug, and DialuxEVO software.